Joel Miller is the protagonist of The Last of Us. From Texas, Joel was a single father in his late 20s when the initial Cordyceps outbreak occurred. Fleeing with his brother Tommy and his twelve-year-old daughter Sarah, they got involved in a firefight with a soldier, and Sarah was mortally wounded and died in his arms, leaving him traumatized. In the 20 years that follow, Joel did whatever he had to do to survive.

Twenty years after Sarah's death, Joel works as a smuggler in the Boston quarantine zone with his friend and partner Tess. While out searching for a former accomplice who stole some of their merchandise, Joel and Tess are tasked by Marlene, an acquaintance and the leader of a rebel militia called the Fireflies, to smuggle Ellie to a rendezvous point. Joel discovers Ellie is immune to the infection. Upon their arrival, Tess reveals she has sustained a bite on the journey and insists Joel find Tommy, a former Firefly, in order to continue the mission. Joel is initially surly and short towards Ellie, though he begins to warm up to her as their journey continues. This is compounded when Joel, having initially asked Tommy to carry on in his place after meeting up with him, changes his mind and carries on as planned. Their bond deepens when Ellie nearly loses Joel to a severe injury, and when he comes to her aid after she is nearly killed by a band of cannibals. Ultimately, Joel shows his devotion to Ellie when he chooses to rescue her from the doctors who plan to remove and examine her brain, as opposed to allowing her to die. To ensure they are not pursued, Joel kills Marlene. Driving away, Ellie wakes up, after which Joel tells her the doctors gave up on discovering a cure. Ellie later confronts him about the events, and Joel swears to her he was telling the truth.